Hotel Diocleziano is located in the center of many of Rome's historical sites. This hotel in Rome is close to the Roman baths, as well as many popular shopping areas, such as Via Nazionale. The Quirinale and Via Vittorio Veneto are within walking distance of the hotel as well. The metro station and the Termini rail station are within easy walking distance of Hotel Diocleziano. Guests will find that many attractions are a short walk from the hotel, and the public transportation is plentiful and close, and can help them reach other areas. The airport is only 30 km from the hotel.

The 35 rooms at Hotel Diocleziano include mini bars, private bathrooms, and more. Guests can utilize the high speed Internet for a fee.

Hotel Diocleziano is a modern hotel housed in a 19th century building. Guests will be able to find complimentary newspapers in the lobby, as well as a 24-hr front desk. The front desk staff can help with making tour reservations. Guests will also be able to enjoy complimentary American breakfasts each morning.